Tuesday, July 30, 2019

Common Private Cord Blood Banking Myths Debunked

You may have noticed that there is a lot of marketing and promotions done by banks nowadays. But what is a cord blood bank exactly? Well, it is a medical bank where doctors extract the hematopoietic stem cells (HSCs) from the newborn umbilical cord and can be preserved indefinitely. You can bank the blood in a private or a public one and can be used later on to treat diseases and illnesses. This may sound like a wonderful medical breakthrough, but there are many myths about private cord blood banking making the rounds. Let us have a look at these myths and break the misconceptions clouding the minds of parents-to-be.
1. Can It Harm My Baby Be Harmed?
Collection of this is in no way harmful to the baby or the mother. The blood that is discarded after birth normally is collected and stored at bank.
2. Private Cord Blood Banks May Send Our Baby's Cord Blood for Research
This is a complete myth as private cord blood banks give exclusive accessibility and control to what you store. They charge you annually for storing this and will give you access as and when you require it in the future. Unlink public banks wherein the blood may be sent further for research purposes.
3. Choose Any Bank, They Are All the Same
Wrong. Private blood banks have to follow stringent norms in terms of quality, cost, location, and need to be FDA-approved and AABB-accredited. However, not all private ones have DA approval and AABB-accreditation. Those who have both, have high annual storage fees and better facilities to store your baby's cord blood for a longer duration.
4. It is Always Better to Store Cord Blood in Private Banks
Many to-be parents often think storing their baby's cord blood in private banks is better than donating it to a public bank. If your family has a history of certain diseases and disorders, then choosing a private blood bank may sound logical. However, there is no such history and you don't even know if you will ever need to access the stored this, then donating this to a public bank is a wise decision.
5. You Can't Treat Your Child With His/ Her Own Blood as it May Be Diseased Itself
This statement does not hold much ground as autologous transplants have been in use for more than a decade. Use of one's own stem cells has helped in the treatment of many diseases ranging from neuroblastoma, lymphoblastic leukemia, etc.
6. This Blood can Remain Viable Only for 10 Years
Current studies have shown, stem cells stored for about 24 years remained viable without any decrease in viability or proliferation. It is even claimed by cryopreservationists these cells can be stored indefinitely in a controlled environment.
7. Cord Blood Banking And Ethical Issues
According to the Indian Council of Medical Research (ICMR), there are certain issues related to the self-use of blood as promoted by such banks. The ICMR guidelines for stem cell research (2013) states there is no scientific basis for preservation of this for future self-use. Thus, this practice is not officially recommended and any use other than bone marrow transplantation apart from clinical trials is termed as a medical malpractice.
8. You Can Decide About Cord Blood Banking Just Before You Deliver
It is not a good idea to make a last-minute decision in most of the cases. Your hospital may not have the collection kit ready during the child's birth. There are many logistics that need to be figured out before you can store this. Thus, make sure you enroll early to this of your choice for smooth and hassle free collection during the birthing process.
These are a few of the common myths that are busted above. this does have many benefits in cases where there is a family history of leukemia or thalassemia. However, it will remain as a personal choice whether or not one should store the blood.
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Impact of Umbilical Cord Blood-Derived Mesenchymal Stem Cells on Cardiovascular Research

Despite having therapeutic advances in the medical fields, we continue to receive destructive outcomes for the patients with cardiovascular diseases. Not only have cardiovascular disorders such as myocardial infarction causing congestive heart failure, become a growing concern for every individual, it emerges as one of the sole cause of deaths in Western Countries.
However, we have too many evidences from clinical trials and medical research, which prove the efficacy and potentiality of stem cell based therapies in treating cardiovascular disorders. They are capable of fostering revascularization of cardiac tissues, regenerating cardiac tissues and also reinstating the cardiac performances.
With several recent experimental studies finding success through the use of different stem cell populations, it raises promising hopes for the patients of a complete relief from the severity of the diseases, and also heavy medical bills. In recent times, there have been a huge application of skeletal myoblasts, embryonic stem cells, endothelial progenitor cells, hematopoietic stem cells and not to mention- the mesenchymal stem cells in biomedical research for the development of regenerative therapies.
That apart, another study in the recent times has showcased a positive outcome for the treatment of cardiovascular disorders using human umbilical cord-derived mesenchymal stem cells.
While human umbilical cord derived stem cells are a useful tissue for combating various adamant diseases, it has become a great potential for us to save these cells through UCB banking, giving us an equal opportunity for future use. As UCB banking provides us with opportunities to preserve these precious cells, the growth of the UCB banking is on the surge as well. Notwithstanding, it is worth discovering the efficacy and importance of UCB mesenchymal stem cells on cardiovascular research, and finding more promises for our health care.
Why UCBMSCs Are A Useful Component In The Research Of Cardiovascular Diseases
MSCs have unique properties to differentiate into a myogenic phenotype in vitro, hence it is capable of alleviating the symptoms of ischemic and nonischemic related cardiac complications. Another study suggested that bone marrow derived autologous MSCs have properties like cardiomyocyte like cells, which reinstated the cardiac functions of a rat with cryoinjury.
And because of this wide array of advantages of MSCs in the heart related complications, UCBMSCs are constantly being used in the research to develop effective strategies to be used for relieving cardiovascular disorders.
In addition to this, for immune deficiency disorders and human blood related diseases, UCB cells has shown some potential properties to replace the HPCs in the clinical setting as a source for research since 1988. At the same time, these cells derived from UCB contain the properties of MSCs as well, and therefore they are effective in treating idiopathic dilated cardiomyopathy as well.
We can have a clearer insight through an investigation theory carried out on mice at the most recent time into the efficacy of UCBMSCs.
Clinical Methods
Mice with cardiac infarction, including healthy mice received UCB mononuclear cells infused with CD34- positive cells through a transplantation. They were observed for 3 weeks.
It was found that both healthy and infracted mice had received UCB cells to their liver, spleen and bone marrow. However, only the mice with cardiac issues had transplanted cells on their hearts. A reduced heart size, coupled with collagen deposits and increased capillary density were signs of their myocardial infarction.
Therefore, this result of the study showed that UCBMSCs have the potential to return to the infarcted heart with transplantation and aid in the growth of heart tissues.
More such uses of UCBMSCs can be developed like its use in cardiovascular research, and we are likely to receive many cells based strategies for tissue regenerations. And this finding will be one day effective in establishing therapeutic treatments in future.
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Friday, July 26, 2019

Attractive New Regenerative Medicine Tool Uses Magnets to Shape and Stimulate Stem Cells

How would it have been if we could develop embryoid bodies (EBs) from individual embryonic stem cells (ESCs) using technology? This could give birth to the development of the regenerative medicines and other therapies, which does not require an external supporting matrix as needed by the traditional regenerative technology to create a coordinated assembly.
All this is possible with a cellular magnetic Legos. A technology developed by the researchers at the Laboratoire Matiere et Systemes Complexes (CNRS/Universite Paris Diderot) is capable of combining cells with the help of magnetic nanoparticles and magnetized miniaturized magnets. In order to differentiate, it does not need any supporting matrix. The best part of this technology is that it can develop any tissues and deform them at will.
An elaborate insight of the study has been detailed in Nature Communications. This tool infused with miniaturized magnets can be used as a great technology in the field of regenerative medicines and also in biophysical studies.
Since the demand of nanotechnology is ever growing for providing an unprecedented solution for diagnosis and regenerative therapy, we can feel its necessity in every sphere of medicines and biosciences. Hence, this finding is another milestone for the development of regenerative tissues or therapies sans an external supporting matrix.
However, for scientists it is not viable to use matrix for the development of cohesive and organized cellular assembly for tissue generation. This is what they find it a great challenge, especially when they have to work on synthesizing thick or large sized organ or tissue. Or sometimes, the stimulation of these tissues is quite tough as they refuse to function properly as opposed to their counterpart cartilage.
Magnetic Cellular Lego At Scientists' Assistance
A new tool developed by the scientists in France, uses magnetized stem cells to alter and stimulate stem cells into 3D shapes. By using external magnets, cells can be magnetized for differentiation, assembly, proliferation and stimulation through insertion of nanoparticles. This way, these cells are turning into cellular magnetic Legos. The magnetic Legos performs as a magnetic tissue stretcher, where mobile magnets captivate aggregate developed from the cells before a second the micromagnet could attract magnetized cells. The experimenting tissues on the magnetic tray behave independently (say compression and stretching) influenced by the two actuated magnets.
The Method Of The Experiments
The first approach of the study was to gauge the capacity of the magnetized cells to differentiate and proliferate as similar as stem cells, and also zap pluripotency characteristic in embryonic stem cells when introduced to nanoparticles. It was aimed at developing the embryoid body applying the differentiation process of embryonic stem cells. We can call embryoid bodies as 3D groups of pluripotent stem cells, which comprise three types of skin cell types. The team further found that nanoparticles do not impact the formation of embryoid bodies in the magnetic stretcher.
In order to form embryoid bodies using magnetized cells, it has more effective outcomes as opposed to the hanging drop method, where embryoid bodies cannot proliferate properly.
The study further showed that the addition of the nanoparticles to the embryonic stem cells do not put any impact on its differentiation process. Simultaneously, the embryoid bodies could move toward the heart muscle in the magnetic stretcher when stimulated by magnetic cells. Thus, it proved that other than living orgasmic cells, the mechanical factors like magnetic cells can take part in the process of cell differentiation too.
We can hope that by using this all-in-technology, we can generate tissues by manipulating stem cells, or use it as a powerful method to enhance biophysical learning possibilities.
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9 Plus Natural Ways to Prevent the Cold and Flu and Stay Healthy

1. The number one way to get the cold or flu is through direct contact. If you know some one who is sick it is wise to avoid direct contact them such as touching or kissing them.
2. Cover you your coughs and sneezes with a tissue and then throw it in the trash immediately. If you don't have a tissue handy cough or sneeze into the inside of your elbow and whatever you do - do not sneeze or cough into your hands. The germs cling to your hands like a magnet.
3. Wash your hand often and regularly for at least 15 seconds with mild soap and water. Don't touch your mucous membranes such as your eyes, nose, and mouth after touching people or objects that many others have contact with. According to the CDC washing your hands if the best way to prevent sickness and spreading disease.
4. Avoid stress as much as possible because it wears our body down and negatively affects our immune system. When our immune system is weaken it opens up our body to be attacked by germs, viruses and disease. Try getting a massage to help lower your stress, listen to music, try meditation and deep breathing, yoga, or have yourself a good laugh with some friends. Laughter is a wonderful way to reduce stress.
5. Exercise regularly because this helps release endorphins into our body that naturally help our immune system stay strong and healthy.
6. Get plenty of sleep and rest. Sleep is also a major factor to having a strong and healthy immune system. According to experts 7-9 hours of sleep is required for the average person. To help you get enough sleep - try having a regular routine of going to bed and getting about the same time every day. Avoid caffeinated drinks, unhealthy snacks and spicy foods near bedtime in fact avoid unhealthy and processed at any time or meal. Stay off of electronic devices at least an hour before bed and that also means your smartphones or checking your e-mails. It will be there tomorrow.
7. Drink at least 8 glasses of water and fluids every day. you need to flush out the toxins in your body and water is great for cleansing your whole body. Organic fruit juices are a good choice to supply your body with extra vitamins and minerals. Try some peppermint water of peppermint tea. It works wonders on clearing congestion and helps you breathe. Try taking a little dab of peppermint essential oil and put it on your temples of under your nose.
8. Make sure you are eating a healthy balanced diet free from processed foods, sugary, fatty, high-calorie, or junk food. Eat plenty of lean protein and organic or local harvest fruits and vegetables to make sure you are getting the proper nutrition for a healthy and strong immune system. Make sure you are eating plenty of citrus fruits that are high in vitamin C.
Try so homemade bone broth. It is loaded with so many essential vitamins and minerals - it is one of the healthiest foods you can consume.
Eat fish that is high in Omega-3 and plenty of leafy greens. Garlic and onions are known to fight off bacteria and viruses that can help prevent the common cold and flu. They also make many foods taste wonderfully delicious - so add all the garlic and onions you can..
Studies have shown that eating real organic or homemade yogurt with live probiotics can reduce your susceptibility to colds by 25 percent. The beneficial bacteria can help the immune system fight off disease.
9. Make sure you get plenty of antioxidants,vitamins and minerals. Taking a supplements of Vitamin A, Vitamin C, Vitamin E can be very helpful and let's not forget about that mighty mineral zinc, It is so important in keeping the cold and flu at bay because it is so good at fighting infections. If you do get sick it can shorten the duration of your illness and because It helps destroy the virus at the back of the throat, therefore you recovery time is greatly shorten.
With these 9 plus tips you can stop the cold and flu and keep yourself and your family healthy by living a healthy lifestyle and make it through the cold and flu season without worrying and feeling miserable.
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Tuesday, July 23, 2019

Commercializing Stem Cell Therapy

So far, we have got to know about the positive applications of these therapies, which are transplanted into the body with living cells to treat, or eliminate the disease from the patient's body. The most common type of cell therapy is the hematopoietic therapy. Harvested from the donor's body for the host to develop bone marrow, it is a well-known cell based therapy, with its self-renewal and differentiation capabilities into many cell types.
Stem cell based therapies have the potential to treat numerous disorders, especially blood and immune related disorders. A wide range of these therapies including allogenic cell therapies, autologous therapies, and mesenchymal these therapies has shown a major breakthrough for curing many medical conditions such as sclerosis, spinal cord injury, diabetes and strokes in the clinical trials. More recently, we have the boon of induced pluripotent stem cells, having the same characteristic as adult embryonic stem cells that can be cultured to produce embryonic stem cells. These cells are important for another key reason- tissue engineering.
Over the last few decades, cell therapies have received medical and commercial successes for emerging as a novel therapeutic option for many cellular dysfunctional diseases. If data are to be believed, the global market of stem cell therapy had touched an average of $410 million revenues by 2009, and the market was expected to grow double and reached a total of 100 million people in the US.
And due to its numerous medical benefits, medical companies and research institutes want to bring its clinical applications from bench to bedside.
Although open to many controversies and debate, we have enough evidence to prove that therapy is indeed an effective therapeutic application to address a range of diseases, including cosmetic procedures like hair regrowth, skin redefining and etc.
In addition to this, the growing number of cell based clinical trails hold true to the potential for stem cell efficacies and its applications. A recent study as of June 2010 highlighted the capabilities of cell therapies through 2000 (approx.) clinical studies on biomedical research.
While the manipulation of embryonic cells is limited and controversial, a greater chance to develop engineered tissues from iPSC is viable for the medical interventions in serious conditions. And this is the underlying reason, why public and society demand for more clinical trials of stem cell based therapies and their applications in the medical fields.
Hence, it is important to commercialize the use of stem cells for rapid development of biomedical research, and improve public health through awareness. Some important aspects of the commercialization of stem cell therapy are as follows as below.
  1. Commercialization aids the development of novel technologies and intellectual property for certain stem cell research, augmenting their value in the therapeutic market.
  2. It aims at stimulating economic growth as well as improving the public health.
  3. It advocates for grants or funds to be used in the clinical research to generate more commercially viable services and products in the market.
  4. It is indeed important for the translation of public knowledge.
Despite these growth factors of commercialization of stem cell therapies, it faces many challenges from specific governing bodies, which hinders its positive endeavors from creating effective and curative treatments for many incurable diseases.In order to take advantage of scientific, economic and medical potential of these cell research; commercialization is indeed a basic requirement, and of course in a compliance with regulators of certain authorities. And when this happens, we would expect to get sustainable and constructive medical benefits through commercialization in the field of this therapy, while respecting the public trusts.
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Building a Functional Lung is Now Possible With Bioengineering

A new study has inched us closer to designing a new lung with the help of bioengineering. A team of bioengineers has successfully created a functional lung with a healthy, perfusable vasculature in an ex vivo rodent lung.
End-stage lung diseases are the third leading cause of deaths around the world. It has only one true cure, a lung transplant. This is not always an option for a majority of the patients as it is an expensive procedure with a survival rate of just 10% to 12% after 10 years. Finding a donor's lung is also very difficult and thus, there is an urgent need for new approaches to saving lives.
Bioengineering a Functional Lung that Breathes
Researchers around the world are looking for ways to cure lung diseases by promoting lung repair and increasing the number of donor lungs. However, lungs are a complex organ with more than 40 different types of cells in the matrix. The surface area between the airway and the vasculature is the size of a tennis court. Thus, bioengineering a functional lung from synthetic or decellularized scaffolds is not an easy task.
Until now all attempts to create a lung have failed. However, a Columbia Engineering team led by Gordana Vunjak-Novakovic, University Professor and the Mikati Foundation Professor at the Columbia University along with N. Valerio Dorrello, assistant professor of pediatrics at Columbia University Medical Center have finally tasted success to an extent. They are the first to successfully bioengineer a functional lung with perfusable vasculature in an ex vivo rodent lung.
Their study (DOI 10.1126/sciadv.1700521) has been published in Science Advances, wherein they talk about how their approach allows the removal of pulmonary epithelium while maintaining the viability and function of the lung matrix and the vascular network.
The New Approach
The Columbia team did not follow the traditional approach of building an organ. Usually, an organ is built from scratch by manufacturing a synthetic scaffold that resembles the shape of the organ. It is then seeded with the stem cells or other precursor cells. As lungs are a complex vascular jungle, most bioengineers have not attempted to build one. However, the Columbia team generated a natural scaffold by removing the rat lung cells using detergents. This led to a lung 'skeleton' consisting of proteins and molecules called extracellular matrix to remain.
The team in their previous experiments using rat lungs stripped the epithelial lung cells that are usually damaged in lung diseases. They also removed the endothelial cells that make up the vascular system. The team has managed to repopulate the functional epithelial cells; however, restoration of the blood supply was a challenge.
The new approach, therefore, attempted to strip only the lung epithelial cells without disturbing the blood vessels. They hoped this approach would lead to better results. The researchers tried an airway-specific method for removal of the pulmonary epithelium. They even aimed to preserve the lung vasculature, matrix, fibroblasts, myocytes, chondrocytes, and pericytes.
After the lung cannulation, they ventilated the lungs and perfused them on an EVLP (ex vivo perfusion system). Intratracheally, mild detergent solutions were injected into the isolated lung for removal of the epithelial cells. The vasculature was protected by circulating a perfusate containing electrolytes and energy substrates. The result was a lung scaffold that had a well-maintained bronchial and vascular architecture. The attachment and growth of human adult, as well as the cell-derived pulmonary cells in the ex vivo bioreactor, becomes possible due to the well-preserved architecture.
The building of a functional lung has become a breakthrough step in the field of bioengineering that has opened many frontiers in regenerative medicine.
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Monday, July 22, 2019

An Unexpected Link: Immune Cells Send a Muscle Injury Signal to Activate Stem Cell Regeneration

A recent study by the Stanford research team has concluded that the immune cells send muscle injury signal to activate stem cell regeneration.
Immune cells activate cells for muscle regeneration and repair which will aid in treating muscle disorders. Studies indicate that a gene Adamts 1 gets switched on in these cells. This is a secret protein that activates satellite cells in case of muscle injury.
But the Adamts 1 does not appear to produce the protein at the injury. There is a white blood cell called macrophage (literally means eaters) which is responsible in producing the protein at the injury site. They travel to the wound and keep it clean and healthy by eating bacteria, the dead cells and viruses. They also release protein to alert the immune system to fight the infection.
While cleaning the wound it also signals the muscle to regenerate. The Adamts 1 also nips a protein known as NOTCH which is found on the satellite cell surface. NOTCH indicates to the satellite cell to stay dormant. When Adamts 1 destroys NOTCH, the satellite cell gets activated, and starts to divide and transform into muscle cells.
There is a direct link between the cells that clean the injury and they also signal it to start regenerating and rebuilding the muscle that was destroyed. This facet is present only in the uninjured muscles.
Macrophages release Adamts 1 which nips the protein of the NOTCH which keeps them in a restful stage. When NOTCH is deactivated the cells start making new muscle.
Mice that have been tested for this Adamts 1 have shown a curious case. It is seen that they have more muscle damage and the muscle stem cells reduce over time and Adamts 1 becomes less capable of repairing the damaged muscle. More importantly it is just one cell that is able signal to the muscle stem cells and stimulate it to differentiate muscle.
These cells are also called muscle stem cells. These lay inactive and only come into action when there is an injury and damage from it. The satellite cell function breaks down due to aging and diseases like muscular dystrophy. These satellite cells drastically reduce in number and also cannot divide any longer which leads to muscle degeneration.
The research also says that this plays an important role in its activation. The study gives a deep understanding of muscle regeneration, and repair that will help in the development of new treatments for various muscle disorders.
Previous studies on a gene called Adamts 1 suggest that it is turned on strongly in the activated satellite cells than the dormant satellite cells. Most important is the fact that a single protein is enough to send a signal to the muscle stem cells and stimulate them and they can differentiate muscles. This makes it a natural mechanism which can be manipulated to help support the efforts of healing and building therapies to improve health drastically.
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Snake Oil Sellers and Health

Someone discovered that I'm a fifty something male so every day my inbox fills up with news of miracle cures for low testosterone and erectile dysfunction. I also get emails about the health benefits of lemon juice, baking powder and apple cider vinegar for conditions from arthritis to diabetes to indigestion. Some of these miracle cures are already in your kitchen, but the majority are potions concocted in a laboratory in Taiwan - and they are going to cost.
I should say at this point, that I am not a medical practitioner and the opinions I express here are based on a dose of common sense mixed with a dram of scepticism rather than on any expert knowledge or extensive research into medical issues.
When I open one of these emails, the typical pitch goes like this:
1. You can't trust the medical establishment - they're in cahoots with Big Pharma to make you ill and keep you ill - type 2 diabetes being the crowning example.
2. Most if not all prescription medicines have dreadful side effects, some of which are worse than the condition you started with.
3. Surgery is a drastic way to make your back/shoulder/knee pain worse.
4. There are various natural remedies for almost every illness known to humanity, but because of pesticides, poor quality control etc you can't just get your medicine from the supermarket. You need supplements. And ours happen to be the best.
5. If we don't have a supplement to sell, we'll sell you a cookery book or a set of DVDs
The same applies to exercise. These health gurus are now telling us that everything we thought was true about exercise is false. Far from keeping you lithe and young, conventional "cardio" and "carb burning" exercise clogs your body with free radicals that accelerate the aging process. Ditch the running, cycling and gym classes and buy our miracle exercise programme: four extremely intense minutes a day and you'll have a physique to die for...
Some of the promises are clearly overblown and result in fairly swift use of the delete button. But the most effective messages are carefully crafted, with references to rigorously controlled trials published in respected medical journals and "case studies" of people like you and me with "before" and after "photos" to seal the deal.
The most pernicious aspect of these emails, though, is the claim that the medical establishment wants to keep you ill so they can make big bucks from your misfortune. Medical practitioners in the US, where almost all my emails originate, may have incentives - for billing purposes - to tell you you're really ill and you need a battery of medications, surgery, physio etc. though I doubt it. But the situation in the UK is very different Here, because of NHS funding and resourcing issues, medical practitioners have more incentive to ration treatment. For example, patients with long-term conditions such as diabetes or hypertension can claim free prescriptions, so what's in it for GPs in keeping patients drug-dependent for life? There is every incentive to minimise the use of surgery and other therapies because of long waiting lists. The NHS even has gate-keeping services to limit demand by offering telephone or online advice. The NHS certainly has no incentive in keeping you ill.
Similarly, because of lower food standards in the US, it might be difficult for many consumers there to access good quality food. That is not the case in the UK at the moment (though post-Brexit things may be different). Here food production and labelling standards mean that consumers can be confident that a pound of carrots will contain reasonable levels of whatever vitamins and minerals are associated with them.
Some gurus are out to sell the benefits of complementary therapies: reiki, reflexology, acupuncture. These may be helpful - or at worst harmless - for minor ailments or for pain relief for osteo-arthritis. However, the danger comes when they are peddled as cures for cancer and heart disease.
Other gurus alert you to the dangers of eating certain foods: "Never eat these five foods!" they scream. Wheat phobia is a fairly common one and seems to stem from the paleo community, who teach that farming is the worst human activity ever. The fear of wheat is now spreading to other grains that were still benign yesterday: oats, rye, barley. Rice and potatoes are also pure poison for the paleos.
Some gurus tell tales of remote Tibetan villages where everyone lives to be 150 because they use some mysterious herb in their tea. It's true that there are "blue zones" where a significant proportion of people live to a ripe old age and in fine fettle. However, all the research indicates that this is never due to a single factor but to a combination of factors such as genetics, diet and lifestyle. For example, remaining physically active and being part of a close community appear to be crucial. You can't replicate these factors in a bottle.
Some advice looks innocuous because there doesn't seem to be any selling going on. For example, drinking warm water, lemon juice and honey every morning. However, to get the "free report" on the miracle that is lemon juice you have to provide your email address, which is then sold to other snake oil sellers, so that like me, you're soon inundated with pseudo-medical advice.
Remember, most of these gurus have no formal medical training at all, and the minority who do have opted for a comfortable living as medical heretics.
When you see a claim for the benefits of taking magnesium or L-Arginine, check it out on a reputable website like WebMD. You will generally find:
1. The claims are overblown, i.e. there is little or no evidence that the herb, spice or mineral has any appreciable impact on serious conditions such as cancer, heart disease etc.
2. A clinical trial on a small group of patients showed some impact on a minor or rare condition - this is the "kernel of truth" that makes the claim defensible in case of litigation.
3. Overall though, the list of proven uses is much shorter than is claimed.
4. There are risks, for example, for pregnant women, the elderly or people using other medications.
If the sales blurb refers to clinical trials carried out at a university or research institute, check directly on the institution's website. Did such a trial take place, and if so, what were the results?
Similarly, check with your country's food and drug regulator. What advice are they giving about this miracle potion?
Always be wary of the snake oil seller's call to action, which usually rounds off a long and tedious email or video presentation:
1. A stark reminder that your condition is wrecking your life.
2. Orthodox treatments are dangerous or ineffective.
3. You have to take responsibility for your health because your doctors and their mates in Big Pharma don't give a damn about you.
4. The answer to your problems is available at a massive discount but you need to buy within the next 15 minutes.
5. Get your credit card ready.
Of course, if you don't buy the miracle cure there and then, you'll get reminder emails for several days afterwards saying the discount is still available for you alone because "we really care about your glaucoma/rheumatism/varicose veins etc."
When I get emails from the gurus, my approach is:
1. Never accept claims for miracle cures unless or until there is clear evidence to support such claims i.e. rigorous clinical trials conducted by a reputable institution such as a university.
2. Never use any supplements without checking that you really need them, and they work. Then check the ingredients and quality control. Read independent reviews wherever possible.
3. Be wary of paying for any diet or exercise programme until you have seen it in action: be sure that you can commit to it and that it will work for you - physically and mentally. Where possible read independent reviews before parting with any cash.
4. Avoid fads such as therapies, lifestyles or superfoods that have no proven efficacy.
In my family, our approach to health issues is:
1. Have regular check-ups with an orthodox medical practitioner. Increase the frequency as you get older or if you have a long-term condition.
2. Only take supplements if you really can't get the vitamins and minerals you need from your diet, such as Vitamin D in the winter, or if your doctor recommends it because of a medical condition or other issue.
3. Use complementary therapies where there is a proven medical benefit and/or where you feel some tangible benefit, such as pain relief, relaxation or de-stressing. Do not use these therapies instead of orthodox medicine, particularly for serious conditions such as cancer or heart disease.
4. If you want to follow a diet or eating plan, find one that suits your likes and life-style. If you want to lose or gain weight, or if you have a condition such as diabetes or coeliac disease, follow proven medical advice for your condition.
5. Follow an exercise plan that suits you, whether it be walking to the shops or running marathons. Exercise should be fun, so find an activity that you can enjoy and commit to. If you can afford it, find a personal trainer who can help you design an exercise programme that works for you and keeps you motivated.
6. If you don't want to eat healthily or do any exercise, be mindful of the potential consequences.
7. If you are a parent or carer, follow this approach for your child or the person you are caring for, as well as for yourself.
If you see an email offering you the elixir of eternal youth, applying a bit of common sense and scepticism could save you £s - and more importantly, do wonders for your health and well-being.
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Health and Wellness Tips With A Long Fitness Life

Your health is your wealth. A healthy man is a wealthy man, literally. You may think of a tycoon who owns so much material wealth but their health troubles them. What is the point of all the material wealth if you cannot enjoy it? The money spent on doctors could have been channelled in other better avenues. Similarly, ever thought of how quick an employee gets replaced at work? You probably fell ill or a colleague passed on. The job vacancy goes up no sooner than the bad news leaves your mind.
Therefore, it is important that you take care of your health. It is with this in mind, we have noted down these health tips. There are simply recommendations. We are free to do more or less, as per what we desire.
1. Drink Water
This may sound cliché but it is very important. Top of the list in good health tips to practise is staying hydrated. The human body functions mainly on water. Take a person who is fasting, they can do away with food but they are allowed to take water. Water keeps you alert and keeps your body functional. At times, people have headaches simply because of dehydration. However, most people are quick to take paracetamol tablets. It is recommended that you take between 6 - 8 glasses of water every day. Stay hydrated and you definitely will remain rejuvenated.
2. Work out
Among daily health tips that we should not compromise is working out. Now, you don't need to have a gym membership. Life is not as complicated. We all want to have the gym membership but what if you don't? You can simply buy a skipping rope and put in the cardio at home. Get a comfortable pair of trainers and have a morning or evening run. If that's too much, walk. If you own a pet, this can be ideal timing for you to bond.
3. Meditate
The career woman today has so much going on in her daily activities. She ought to be a wife at home, mother and deliver at work. It is very easy to lose yourself when so much is expected of you. Among the health tips for women would be embracing meditation. Most people say they don't have time for such but if it is important, you find time for it. Take time alone and just get lost in your positive thoughts. Visualize or even take part in yoga. You take control of your emotional health particularly which is very important.
4. Sleep well
Sleep is a very debatable subject. Some people prescribe 8 hours of sleep while others prescribe 6 hours. In the same line of thought, you hear of very successful people who sleep for 4 hours and are very functional. Therefore, my recommendation is sleep well. It is not the quantity but quality of sleep that counts. If you sleep for 10 hours and it's a noisy place, you won't rest well. You can however sleep for 2 hours in a very serene environment and get up very energetic. It is the quality that counts, not the quantity.
A power nap in the afternoon is said to keep one youthful. I don't know how true it is but there could be truth to it. What I know is that when you feel sluggish in the afternoon, a power nap goes a long way. There is no point of dragging through your tasks yet you can just sleep for ten minutes and be rejuvenated. However, do not be a serial afternoon sleeper and call it a power nap. That is outright laziness.
5. Eat well
Among the good health tips to practise on a daily is your diet. Having a balanced diet is very important. Your body will not lack anything. Similarly, with food it is the quality and not quantity that matters. You may eat so much but your body will only take up what it needs. That roast beef can be very tempting but your body will only take up the amount of protein needed. Just have the appropriate serving for you. What is not used up ends up being fat in your body.
6. Laugh more
As absurd as it sounds, this is the easiest good health tip you can utilise. We live in a world where everybody is focused on getting things done. People no longer savour the taste of good food. People can't smell well brewed coffee. It is sad. People's moods are at an all time low. To avoid this, just afford a good laugh each day. Find humour in the little things. If laughing is tedious, smile. You never know who you will smile at and they will have a great day just because of your smile.
7. Socialise
Perhaps you are wondering what this means? In the office setting, people don't necessarily socialise. Everyone is doing what brought them there and are quick to head home as soon as they are done. Not many people would say they are close to their colleagues. We don't know what challenges our colleagues may be facing at home. Similarly, people don't know if you have challenges.
It is a great daily health habit to socialise especially with your loved ones. Make time to be with your family. This is perfect to get away from the hustle of making a living. Through family and loved ones, you get to appreciate what life has to offer. You count your blessings and just soak in each moment.
Leading a healthy lifestyle is an option each of us can make. It can be challenging however, since not many people appreciate healthy living. Or maybe they do, they are just not willing to put in the work. Therefore, be the agent of change. You can exemplify what healthy living is like. If you don't practise any of the above daily healthy habits, there is hope. Just practise with one. Increase your water intake or just sleep a bit better. With time, you will reap the benefits.
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Monday, July 15, 2019

Argan Oil - The Most Exclusive Natural Oil

The argan tree (logically known as argania spinosa) becomes just in one place on the planet: in the south-west of Morocco.
The neighborhood ladies would process around 30 kilos of Argan organic products in right around 14 hours of unadulterated diligent work, just to increase enough Argan parts for 1 liter of its uncommon oil.
Contingent upon the sort of the Argan oil removed (culinary or corrective), this God-sent valuable blessing discovers use in a wide assortment of life regions.
Not exclusively it's a profoundly pined for fixing in relatively every gourmet food these days, yet in addition it picked up acclaim in pharmaceutical and also in beautifying agents and excellence fields.
The Argan tree is one of the most established trees on the planet and is currently found in an intramontane territory with low normal precipitation covering in excess of 2,560,000 hectares.
It becomes just in Morocco and in light of the existential noteworthiness for the locals, the UNESCO has proclaimed the region a secured Biosphere Reserve.
No big surprise local people call it the "tree of life" on account of its significance and as it gives them timber, charcoal, nourishment for their dairy cattle and the celebrated oil, which is viewed as a standout amongst the most profitable sustenances on the planet in the most recent decade.
Separating Argan Oil
The collect time of the Argan organic products is from July to August.
What's more, instead of the olive tree, the argania spiniosa can't just be shaken to accelerate the collecting system.
Consequently, the ladies are obliged to gather the natural products starting from the earliest stage fell the rest from the tree utilizing stones in a backbreaking procedure.
What likewise solidifies the reaping venture, is the trees' unpleasant and prickly contorted stems.
What's more, albeit numerous individuals trust that most of the Argan oil on the business sectors today is removed from the natural products gathered by goats, this is a long way from being valid, essentially in light of the fact that the amount of Argan organic products expected to fulfill the progressing and expanding overall request, is a long ways past what any crowd of goats can process.
In the wake of opening the Argan nuts, which may contain a few almond-molded pieces, the ladies either generally cook them to refine the taste lastly crush them utilizing a hand-stone plant to extricate the culinary Argan oil or they process them normally to yield the restorative one.
In the culinary rendition, the batter increased in the wake of granulating the cooked parts is hand-manipulated utilizing high temp water and afterward squeezed to isolate the oil from the rest.
Present day Argan Oil Production
These days, to accelerate the generation procedure, a major number of producers utilize machines to extricate Argan oil, particularly the corrective one.
On account of restorative Argan oil, there's no water utilized and the pieces are squeezed normally without broiling.
This is what's presently known as "chilly squeezed".
However, regardless of the alternatives current innovation is putting forth, the conventional generation of this extraordinary oil is making strides again in view of the high Argan oil quality achieved along these lines.
Fortunately, in the two cases, to send out Argan oil outside of Morocco, the maker and/or exporter must give consistence records demonstrating his/her oil is regarding thorough quality and cleanliness rules.
This guarantees, among others, the oil was created in a domain cordial, and biologically maintainable way.
Argan Oil In The Gastronomy
As I expressed previously, in the most recent decades, Argan oil has picked up acclaim in the restorative and excellence industry, as well as ended up one of the overall very looked for after fixings in the gourmet cooking.
Because of its unpretentious nutty flavor, it discovers utilizes as a remain solitary dressing or as a critical extravagance fixing in plates of mixed greens, vegetables, fish and meat dishes to give some examples.
Besides, the culinary adaptation is healthy to the point that it deservedly surpassed olive oil on account of its common organization.
Numerous famous gourmet specialists immediately perceived that, because of its diverse uses and advantages, the culinary Argan oil plays in an indistinguishable group from truffles and caviar.
This is additionally reflected in the cost of this valuable oil: One liter of bona fide newly separated and natural culinary Argan oil costs in the vicinity of 90 and 120 Dollars relying upon the season!
Argan Oil As A Skin And Hair Serum
Despite the fact that the culinary form can be utilized for both kitchen and additionally corrective purposes, yet here is the restorative (otherwise known as. chilly squeezed) one a herald.
It has an incredibly magnificent impact on skin, nails and hair.
On account of its exceptionally dynamic and powerful fixings, not just it calms harmed skin, nails or hair, but on the other hand it's a perfect answer for saturate, hydrate delicate, maturing and/or imperfect skin, fragile rowdy dry hair and frail nails.
Some Medical And Medicinal Properties
This fluid gold isn't just a delicacy, yet additionally a wellbeing solution and a genuine fortune essentially due to the wide rundown of the important parts contained in that.
It has been clinically-turned out to be the oil with the most elevated convergence of fundamental unsaturated fats (more than 80 %) - for the most part the linoleic and oleic corrosive.
Moreover, other than being rich in alpha-tocopherol, which has the most elevated vitamin E action, it additionally contains an astoundingly high dosage of normal cell reinforcements which help secure against hurtful free radicals and other ecological anxieties.
It's additionally essential that Argan oil turned into a sort of a specific enthusiasm to researchers because of its substance in schottenol and spinasterol.
All things considered, the locals in Morocco successfuly utilized this for a long time as a conventional multitasking solution for:
Stomach torment
Intestinal issues
Heart and circulatory issues
Sunburn
Sanitizing wounds
Mitigating bug chomps
Curing cuts
Skin break out
Chicken pox
Skin inflammation
Ailment
Joint torment
Hemorrhoids
... furthermore, numerous different issues and infections.
This is in no way, shape or form a "total" guide about Argan oil.
This rare regular fortune has wide advantages and uses a list that I could discuss relentless.
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Balance Is Key

I can almost guarantee that if you've taken any sort of health class, no matter if it was voluntary or forced by your high school, you've learned all about a balanced diet. You've found the importance of figuring out a way to have your cake and eat healthy too.
When it comes to a healthy lifestyle, I find it important to work out once a day and eat healthy throughout the work week. Let's be honest, the thought of a strict no carb diet is dreadful, and how many times can we actually say it's something we've followed through with? I know for me, the word diet and the thought of a dramatic change are too intimidating to even think about. Instead, I've reverted to a lifestyle with a balanced routine.
As for working out, I have given myself the goal of sweating for at least 30 minutes a day. It gives me the "I did something good for myself" feeling with the "OK I can do this" mentality. I chose 30 minutes a day because it's not only doable but it's also exciting to think I get to set aside a half hour to be with myself, my music, and not care about what everyone else is doing.
Similar to my workout regimen, I have set a limit to going out only on the weekends, except if there's a special occasion. Alcohol consumption is tough on the body and paired with the loss of sleep can cause you to eat more and turn into a cycle of unhealthy chaos. I learned the importance of this balance by first cutting out alcohol altogether, only to experience the pendulum swing to the more common side of casual and social alcohol intake. It took me a while to develop an understanding of how my body reacts to certain spirits, and how often I can drink without putting a damper on the next few days.
For me, finding a balance between dining out and eating in has been nothing short of difficult. From my friends asking me if I want to go to dinner or the thought of not wanting to cook, finding moderation here is tough. Throughout college, I found it difficult to say no to going out to eat because it was social and I was exhausted from my day. However, once I began to meal prep, the game changed for the better. I started to give myself limits once again and told myself if I ate in at least three nights a week, I could go out to dinner on the weekends without feeling guilty.
Balance in life is difficult to find, through the hectic demands of work and the little time we have left for ourselves at the end of the day, I have found it important to balance the few parts we have control of.
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CIRM-Funded Scientists Discover a New Way to Make Stem Cells Using Antibodies

We know how antibodies perform in our body to restrict the foreign invasions, so that we can protect ourselves from various illnesses caused by viruses and bacteria.
Other than these usual physiological activities, they are found to have lent their hands in the development of Induced Pluripotent Stem Cells by using external parameters. This, we can take as a major breakthrough in the field of medical science, which could be effective in producing different drugs, and medicinal therapies to combat a range of diseases.
In a recent research by the scientists at The Scripps Research Institute (TSRI), it has been proved that antibodies could be a useful component to a new approach as "reprogramming" ordinary adult cells into stem cells or induced pluripotent cells. And to do the "reprogramming" techniques into the DNA's of the adult cells, no invasive procedures are needed to be followed as is with the "reprogramming of stem cells in the human body".
We already have an insight into how induced pluripotent cells act to differentiate into any cell types and proliferate in the body. With potentials like self-renewal, iPSCs are ideal to be used as a model to identify the etiology of diseases, find new drugs or therapy using stem cells of patients. However, the same functions can be executed by the human antibodies too. This is what scientists at the Scripps Research Institute (TSRI) have focused on this new development. The finding of the study has been made available online in the Nature Biotechnology.
Why Antibodies are Better Than iPSCs?
The process of developing iPSCs involves a manipulation of the genome in the DNA of fibroblasts, found in the skin or connective tissues. These cells could easily be converted into stem cells or iPSCs by adding four transcription gene factors of the DNA of these cells. However, the antibodies as found by the scientists do not follow the same path once introduced to the mature cells, and replace three key transcription gene factors to bind to the proteins of the cells.
Using four transcription genes,s including Oct4, Sox2, Klf4 and c-Myc into the nucleus of the mature or adult cells derived from the patients' own cells, iPSCs are developed for a variety of medical purposes, say organ regeneration or cell therapies. There have been a few evidences of risks of producing iPSCs cells, hence we fail to experience much practical use of these cells in the medical field.
The development of iPSCs cells depend on the OSKM theory, meaning using these four protein factors and encoding them, they reprogram cells into induced pluripotent cells.
However, the insertion of those proteins into the genes can invite the attack of viruses, or overproduction of nuclear manipulation techniques may cause cancer to the DNA cells. On the other hand, the production of iPSCs through nuclear reprogramming fosters the collections of different variable properties.
While antibodies do not use any extra DNA as iPSCs to reprogram mature cells into stem cells or iPSCs, it takes into account only three key transcription gene factors excluding the fourth transcription gene factor Klf4.
Hence, iPSCs derived from antibodies could have fewer mutations, and better properties to be used as an effective model in the lab.
The Process Of The Study
The research was carried out on a collection of 100 million human antibodies to examine if any of the antibody could develop iPSCs by replacing OSKM transcription factors. The process was examined on the fibroblasts of mice, and cultured in the lab using first two factors of OSKM such as Oct4 and Klf4. Later on, the entire library of antibodies was placed in the culture tray to find a replacement of functions of other two gene factors such as Sox2 and c-Myc. The study had a positive outcome with a development of iPSCs with antibody triggering the DNA sequencing response. It focused on the replacement of Oct4 using the same technique. However, it was not possible to find any replacement of fourth transcription gene factor Klf4.
The objective is now more concentrated on finding a fourth gene factor replacement to make the whole process shifted on antibody's insertion for iPSCs production. And once we would be able to do it, we will have less number of negative outcomes.
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