Despite
having therapeutic advances in the medical fields, we continue to
receive destructive outcomes for the patients with cardiovascular
diseases. Not only have cardiovascular disorders such as myocardial
infarction causing congestive heart failure, become a growing concern
for every individual, it emerges as one of the sole cause of deaths in
Western Countries.
However, we have too many evidences from
clinical trials and medical research, which prove the efficacy and
potentiality of stem cell based therapies in treating cardiovascular
disorders. They are capable of fostering revascularization of cardiac
tissues, regenerating cardiac tissues and also reinstating the cardiac
performances.
With several recent experimental studies finding
success through the use of different stem cell populations, it raises
promising hopes for the patients of a complete relief from the severity
of the diseases, and also heavy medical bills. In recent times, there
have been a huge application of skeletal myoblasts, embryonic stem
cells, endothelial progenitor cells, hematopoietic stem cells and not to
mention- the mesenchymal stem cells in biomedical research for the
development of regenerative therapies.
That apart, another study
in the recent times has showcased a positive outcome for the treatment
of cardiovascular disorders using human umbilical cord-derived
mesenchymal stem cells.
While human umbilical cord derived stem
cells are a useful tissue for combating various adamant diseases, it has
become a great potential for us to save these cells through UCB
banking, giving us an equal opportunity for future use. As UCB banking
provides us with opportunities to preserve these precious cells, the
growth of the UCB banking is on the surge as well. Notwithstanding, it
is worth discovering the efficacy and importance of UCB mesenchymal stem
cells on cardiovascular research, and finding more promises for our
health care.
Why UCBMSCs Are A Useful Component In The Research Of Cardiovascular Diseases
MSCs
have unique properties to differentiate into a myogenic phenotype in
vitro, hence it is capable of alleviating the symptoms of ischemic and
nonischemic related cardiac complications. Another study suggested that
bone marrow derived autologous MSCs have properties like cardiomyocyte
like cells, which reinstated the cardiac functions of a rat with
cryoinjury.
And because of this wide array of advantages of MSCs
in the heart related complications, UCBMSCs are constantly being used in
the research to develop effective strategies to be used for relieving
cardiovascular disorders.
In addition to this, for immune
deficiency disorders and human blood related diseases, UCB cells has
shown some potential properties to replace the HPCs in the clinical
setting as a source for research since 1988. At the same time, these
cells derived from UCB contain the properties of MSCs as well, and
therefore they are effective in treating idiopathic dilated
cardiomyopathy as well.
We can have a clearer insight through an
investigation theory carried out on mice at the most recent time into
the efficacy of UCBMSCs.
Clinical Methods
Mice
with cardiac infarction, including healthy mice received UCB
mononuclear cells infused with CD34- positive cells through a
transplantation. They were observed for 3 weeks.
It was found that
both healthy and infracted mice had received UCB cells to their liver,
spleen and bone marrow. However, only the mice with cardiac issues had
transplanted cells on their hearts. A reduced heart size, coupled with
collagen deposits and increased capillary density were signs of their
myocardial infarction.
Therefore, this result of the study showed
that UCBMSCs have the potential to return to the infarcted heart with
transplantation and aid in the growth of heart tissues.
More such
uses of UCBMSCs can be developed like its use in cardiovascular
research, and we are likely to receive many cells based strategies for
tissue regenerations. And this finding will be one day effective in
establishing therapeutic treatments in future.
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