How
would it have been if we could develop embryoid bodies (EBs) from
individual embryonic stem cells (ESCs) using technology? This could give
birth to the development of the regenerative medicines and other
therapies, which does not require an external supporting matrix as
needed by the traditional regenerative technology to create a
coordinated assembly.
All this is possible with a cellular
magnetic Legos. A technology developed by the researchers at the
Laboratoire Matiere et Systemes Complexes (CNRS/Universite Paris
Diderot) is capable of combining cells with the help of magnetic
nanoparticles and magnetized miniaturized magnets. In order to
differentiate, it does not need any supporting matrix. The best part of
this technology is that it can develop any tissues and deform them at
will.
An elaborate insight of the study has been detailed in Nature Communications.
This tool infused with miniaturized magnets can be used as a great
technology in the field of regenerative medicines and also in
biophysical studies.
Since the demand of nanotechnology is ever
growing for providing an unprecedented solution for diagnosis and
regenerative therapy, we can feel its necessity in every sphere of
medicines and biosciences. Hence, this finding is another milestone for
the development of regenerative tissues or therapies sans an external
supporting matrix.
However, for scientists it is not viable to use
matrix for the development of cohesive and organized cellular assembly
for tissue generation. This is what they find it a great challenge,
especially when they have to work on synthesizing thick or large sized
organ or tissue. Or sometimes, the stimulation of these tissues is quite
tough as they refuse to function properly as opposed to their
counterpart cartilage.
Magnetic Cellular Lego At Scientists' Assistance
A
new tool developed by the scientists in France, uses magnetized stem
cells to alter and stimulate stem cells into 3D shapes. By using
external magnets, cells can be magnetized for differentiation, assembly,
proliferation and stimulation through insertion of nanoparticles. This
way, these cells are turning into cellular magnetic Legos. The magnetic
Legos performs as a magnetic tissue stretcher, where mobile magnets
captivate aggregate developed from the cells before a second the
micromagnet could attract magnetized cells. The experimenting tissues on
the magnetic tray behave independently (say compression and stretching)
influenced by the two actuated magnets.
The Method Of The Experiments
The
first approach of the study was to gauge the capacity of the magnetized
cells to differentiate and proliferate as similar as stem cells, and
also zap pluripotency characteristic in embryonic stem cells when
introduced to nanoparticles. It was aimed at developing the embryoid
body applying the differentiation process of embryonic stem cells. We
can call embryoid bodies as 3D groups of pluripotent stem cells, which
comprise three types of skin cell types. The team further found that
nanoparticles do not impact the formation of embryoid bodies in the
magnetic stretcher.
In order to form embryoid bodies using
magnetized cells, it has more effective outcomes as opposed to the
hanging drop method, where embryoid bodies cannot proliferate properly.
The
study further showed that the addition of the nanoparticles to the
embryonic stem cells do not put any impact on its differentiation
process. Simultaneously, the embryoid bodies could move toward the heart
muscle in the magnetic stretcher when stimulated by magnetic cells.
Thus, it proved that other than living orgasmic cells, the mechanical
factors like magnetic cells can take part in the process of cell
differentiation too.
We can hope that by using this
all-in-technology, we can generate tissues by manipulating stem cells,
or use it as a powerful method to enhance biophysical learning
possibilities.
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