Our
immune system is calibrated to provide us with specific protection
shields against harmful diseases, and other conditions too. On being
influenced by the excessive active cells and intruder cells, interfering
with its physical functions, our immune system is more likely to lose
its strength to fight diseases, and as a result it causes a range of
autoimmune diseases or different types of leukemia.
Immune cells
mostly referred to as T cells can reverse the effects of these defective
cells and reinstate the balance through a reprogram technique. With a
reprogram technique manipulating the performances of certain immune
cells, we can remain unaffected to the prevalence of different diseases,
including cancers and psoriasis. This also fosters the development of
new treatment options.
This is how the scientists at the Gladstone Institute have expressed about their latest findings. A renowned journal Nature has published about this metabolic mechanism in an elaborate way.
How Much Effective Is the Whole Method Of Reprogramming T Cells?
The
whole method of manipulating T cells or immune cells, advocates for the
reduction of anti-inflammatory reactions, developed in the immune
system through pro-inflammatory genes. So, the inflammation causing
factors in the immune system could be curtailed using this modification
theory.
On the basis of the findings, there are two types of cells
termed as Effector T cells and Regulatory T cells. These two cells play
a key role in regulating our whole immune system. The Effector T cells
build a shield against the pathogens so as to protect us from the
vulnerability to infections, once the immune system gets charged up. The
Regulatory T cells on the other hand, restrict further attacks of the
pathogens to the healthy parts of our body.
With Regulatory T
cells being converted into Effector T cells under the influence of
reprogramming technique, a molecule drug appears to be a great precursor
in the whole process. So, this method seems to be effective in
converting one cell into another cell type.
The conversion methods
show promise to find the etiology of the disease, especially
auto-immune diseases, making it possible to eradicate the diseases from
its root. Say, when effector T cells are charged up excessively in the
body in the presence of autoimmune disease, the T cells expose the body
to harmful effects. But by converting these Regulatory T cells, the
balance of the immune system can be reinstated, followed by the
reduction of hyperactivity.
Treatment for Immune-Oncology
Another
way, the study is intensifying our hopes against the deadly effects of
cancers and tumor related disorders. We can achieve a better outcome for
immune-oncology and cancer treatments. The process is ineffective in
influencing the cancer cells though; it defies its attacks on the
activation of the immune system.
Since cancer cells seem to be
stronger to influence Regulatory T cells, they make a room in the immune
system for the growth, and hence, the detection becomes quite tough.
But, the findings could help us in detecting cancerous cells and
destroying them by strengthening the immune system through a conversion
of Effector T cells from Regulatory T cells.
More Scopes for Stem Cell Therapies
It
also brings a revolutionary milestone for stem cell therapies. With the
development of Regulatory T cells, we could reverse the effects of
graft-versus-host-disease, and also make our body adjust to the
newly-transplanted cells.
With a reprogram technology for immune
system, we could defend ourselves from a range of diseases, once which
were termed as unavoidable medical cases. Hence, we can live our dream
to make a disease-free world in the future.
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