A recent meta-analysis of clinical trials found that each of the five
FDA-approved weight loss medications was successful in achieving at
least 5% weight loss in a year, compared with participants who had been
given a placebo. Let’s have a look at these drugs.
1.Orlistat
It comes in two forms- Orlistat 60 mg- Alli and Orlistat 120 mg-
Xenical. It causes 30 % of fat and calories to be absorbed into the gut.
Side effects of this medication include diarrhoea from including fatty
foods when you are on this medication. Xenical was approved as a
prescription product by the U. S. FDA in 1999 for the obesity problem.
In 2010, the FDA issued a safety warning about this drug stating that
some people who take Orlistat are potentially at risk of liver failure
and so the drug label started including new safety information about the
liver injury.
2.Phentermine And Topiramate
It comes with a brand name of Qsymia.
Phentermine helps in treating short-term weight loss, whereas
topiramate triggers satiety. After a year of taking Qsymia, patients
lost, on average, 8.9 per cent of their weight, those who were on a high
dose and those taking the recommended dose experienced a 6.7 per cent
weight loss compared to those people who were taking treatment with a
placebo. Qsymia is not recommended for people having glaucoma or
hyperthyroidism. Patients who have recently got a heart attack or stroke
are also not recommended to take this medication.
3.Lorcaserin Hydrochloride
It comes with a brand name of Belviq.
This drug works on appetite and metabolism and keeps them appropriate.
It was approved for adults with a BMI greater than 30, and for those
adults with a BMI of 27 or more who also have high blood pressure, high
cholesterol or type 2 diabetes. The drug works to stimulate the
serotonin 2CV receptor in the brain, which may help patients feel fuller
after eating less. In clinical trials, 38% of patients lost at least 5
per cent of their total body weight, as compared to 16% per cent of
patients treated with a placebo.
The FDA reports positive
effects on glycemic control for patients with type 2 diabetes. The
drug’s negative side effects include migraines. For patients with
diabetes, common side effects also include hypoglycemia, headache, back
pain, cough, and fatigue. Memory and attention problems, as well as
serotonin syndrome, are other side effects to note.
4.Naltrexone Hydrochloride And Bupropion Hydrochloride
It comes with a brand name of Contrave.
This is an extended-release mixture of two FDA-approved medications,
antidepressant and smoking cessation medication and a drug that treats
alcohol and opioid addiction. FDA approved it in 2014 for adults with a
BMI>30 and for adults with a BMI of twenty-seven or more who also
have type 2 diabetes or high cholesterol.
5.Liraglutide
It comes with a brand name of Saxenda.
This drug is a glucagon-like peptide-1 receptor agonist, a class that
other drugs used to work on diabetes fall into. It should not be used
with any other drug in this class, even Victoza, as it has the same
active ingredient at different doses.
These new drugs for weight
loss approved by the FDA in the past 3-4 years heaved a sigh of relief
for those who are tired of using the conventional weight loss
medication. Now, with these they can hope for the perfect body and best
personality, leaving behind the extra fats.
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